Task 1, Unit 1 – Section 1 & Mind Map

Q1:

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Q2:

To what extent can deep learning models [1] accurately predict matching donor and patient typing in Bone Marrow Transplantation [2] using historical matching result data from previous donors and patients. Would the implementation of AI help provide better matches of patients to donors than current algorithms [3]?

The following hypothesis are assumed:

H0: AI provides no insight or improvement on what is already known or fails completely.
H1: AI provides equivalent matching to current human designed algorithms.
H2: AI surpasses human designed algorithms and provides further suggestions and insights.

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References:

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[1] Proquest, “Deep learning”, [Online] Available: https://www.proquest.com/docview/1685003444?accountid=130472 [Accessed 04/06/2023]
[2] NHS, “Stem cell and bone marrow transplants”, [Online] Available: https://www.nhs.uk/conditions/stem-cell-transplant/ [Accessed 05/06/2023]
[3] Elsevier, “The role of HLA matching in unrelated donor bone marrow transplant”, [Online] Available: https://pdf.sciencedirectassets.com/271972/1-s2.0-S0041134500X00395/1-s2.0-S0041134500013191/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEIz%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIEvuDsU8F3JS8Rkd4r%2BnM4ykb5q98cnuzBAZb8ysdNbCAiEA1%2FXMfKrL10ZKD%2FrWelHbzqxgBBQlwrsEH6bJUDUFRm4quwUI1P%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAFGgwwNTkwMDM1NDY4NjUiDOXzhX0lh6ciDXiX1CqPBUEbbXBk2UnjsDwKQ77%2FYqHuTuz5izGjer2riyNqZgnJEiidkw6k2YptpPbfRc5ARmIfFz%2FpM0ApccySqBxaMd6DvFwKTPSPGQDrMEeLQsptyvEAK%2BT%2FElBR5fGI5op5%2BypDFFORIqjmqpKe78Azr4ZvwqS6AWaqKwxPZ%2FmzXqg5%2FsKzpIAqP1D5sG5bHmU8yEGK7qWmeS%2Bk%2BLkX%2FN3SOvhOOLpCJSCutkbw0J2PfuMdVg0M6NwD9wsVAM7gGLH8tqPmGVqHprWC1Ftxivw0Ughx0V%2FZiAbeVT95EooEHv2UgZThXtggfSzLcleuV%2BsaRaN0QNTUINOz9owz4Jz4wKNvvJoYY9c58ktBPhQYD%2BXdAf22scWO16Af41aHfuDx1TrTowGoaizpxlDtHAnO651egYiIIPFAl2tFCt%2F0UL29%2BJwFdrOzkd5%2B1EyXCPdffZAA0kPzhIgiqALAbPV8gZ1D622hc4jxiJtBL2VIA0NIEhbSb%2FbJSlVzipqQvhk056leQdUCdtXYsf%2F5rLUuz9VCLFAmQhFeCduiCC2El3HqMaXWMJq6so2kxbktsfHWJbjrZjkDDEgNtF2OK%2BkRr6PjXa9G%2BM7CvdNaF2NtDC8b6CxbzdWVK9OVzGzAZSyHeRw7pSrxsI4h2o2BawioBfJZvEQrz9nNoSpWjuf%2FclgzOY1RqqKf%2BY7YH3Ws0YXbp7OZmc%2BkQ3PT%2FtXauzS2SWHCu9IfajA%2FHlJB8n%2BxkbrYrFCgbfB8H6p45Qkq3KCKaTOZac8vHF8NNEU3i8oS0HATyqnKg%2Bi6dQTyR0QGlE0vjIsVICWz6r%2F7HISpDedYG2vHfVNAWRbLiJVLmA7Mz79xwNBlDRHSVMLgbxeWAMAwuvubpAY6sQFg%2B5oO8%2FDCG8BzPWnISmHjeCZzupNw7j2NOx1Y%2FInZhZBpylrQWIiHwbQ6X8pCmmFeXmcVadRRwLfaKJT3280pj6O3n2Iw2RsfJAUNEuKkyf7%2BbbbMDeM7YrjiE0525dkeRqBwFe3%2Ftydpw6CPfcFc%2BF2d8rtRCKrZCy57elzRxusVbB5vEnSs0p9zrjuAdWnmXd9D3oaC%2FqvqDcW79kqG4t%2BQ8Wjgv6gx2qiHZTrq7ZM%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20230612T114947Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYXS2Q7T4Z%2F20230612%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=02277f528eef9a549cf7f72f042cc43bfe79b84e7770fddca82b3f044e7289ca&hash=0ad7358bbf712e84939771242a1064fe69daec4359cb64d637f2947dc412a7c4&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0041134500013191&tid=spdf-7156838b-427c-44a8-8ac5-69d9b6647f11&sid=50dbfe0f3fdc02481b893e681a487031fe0cgxrqb&type=client&ua=01015804525f04075105&rr=7d61df5c4de3dc51&cc=gb [Accessed 05/06/2023]
[4] National marrow donor program, “HLA-matching guidelines for unrelated marrow transplants”, [Online] Available: https://www.sciencedirect.com/science/article/pii/S108387910300329X [Accessed 05/06/2023]
[5] , “”, [Online] Available: [Accessed 99/99/2023]